Middle River Framboise Wilderness Area protects a representative portion of the Mira River Drumlin Plain natural landscape.

A defining feature is the well-drained drumlin landforms found throughout. These are surrounded by imperfectly to poorly drained areas, streams and lakes. The most productive forest occurs on the drumlins, where up to 200 year old yellow birch and sugar maple grow. Various conifer forest types are most common on the surrounding lands. Extensive wetlands occur throughout.

Although this wilderness area has no managed trails and is largely inaccessible, much of it is surrounded by a forestry road network. Anglers enjoy trout fishing on several of the larger lakes. The area is located a short drive from Cape Breton's population centre in Sydney.

The wilderness area was designated in 1998, with a remote 21 hectare parcel added in 2022, after Crown title was confirmed.